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Bhaskar, J.
- Clinical Efficacy and Anti-Inflammatory Property of Curcumin in Periodontal Disease:A Systematic Review
Authors
1 Department of Periodontics, Sree Balaji Dental College and Hospital, BIHER, Chennai, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 12 (2019), Pagination: 1163-1166Abstract
Periodontitis is a chronic inflammatory condition, caused by bacteria, that leads to the destruction of supporting tissues around teeth, resulting ultimately in significant morbidity as a result of infection, pain and tooth loss. Curcumin, from the ischolar_main of the turmeric plant Curcuma longa, is an extended pseudo symmetric polyphenol. In recent years, in vitro and in vivo research has suggested that curcumin has anticarcinogenic, antiviral, antioxidant and anti-inflammatory effects. The aim of this review is to systematically evaluate the clinical efficacy and anti inflammatory property of curcumin in periodontal disease. An electronic search was carried out using the keywords ‘curcumin’, ‘periodontal’ and ‘periodontitis’ via the PubMed/Medline, ISI Web of Science and Google Scholar databases for relevant articles published from 2009 to February 2019.Keywords
Curcumin, Periodontal, Periodontitis, Inflammation.- Comparative Evaluation of Periodontal Status and II-6 Levels in Chronic Kidney Disease Patients and Healthy Individuals
Authors
1 Post Graduate Student, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
2 Professor, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
3 Head of the Department, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
4 Reader, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 3268-3273Abstract
Background: Chronic kidney disease (CKD) is a veryreal and growing problem, as indicated by demographic trends. Presence of undiagnosed periodontitis may have significant effect on the medical management of CKD patient as its been found to contribute to systemic inflammatory burden.This study evaluate and compare the periodontal status and IL-6 levels among CKD, periodontitis and Healthy patients.
Materials and Method: Whole serum samples werecollected from 80 patients who were further divided into four groups; healthy (n=20), periodontitis (n=20), HD (n=20), PD (n=20). Serum IL-6 concentrations were determined by Standard enzyme -linked immunosorbent assay.
Results: Indicates the IL-6 levels in the studypopulation. The mean IL-6 value being highest in pre-dialysis (92.695) compared to dialysis (53.112), periodontitis (9.22) and healthy individuals (9.6). ANOVA results show a significant increase of IL-6 levels in the pre-dialysis group compared to alter groups. No significant change on PPD was appreciated.
Conclusion: Treatment of moderate to severeperiodontitis in ESRD populations will result in decreased IL-6 levels and, more importantly, decreased incidence of atherosclerotic complications awaits the result of interceptive clinical trials in this population